Rate of functional decline in AD, VaD and DLB

 
   Lead Investigator:    Dawn Gill
   Institution      :    NACC
   E-Mail           :    dpgill2@u.washington.edu
   Proposal ID      :    55


   Publications:


1  Gill D, Koepsell T, Hubbard RA, Kukull, WA
   Risk of 1-year Decline in Functional Activities in Dementia with Lewy Bodies and Alzheimer's Disease
   Abstract  Neurology,74:A431,2010,

   PUBLISHED



2  Gill DP, Hubbard RA, Koepsell TD , Borrie M, Petrella RJ, Knopman D,  Kukull WA
   Differences in rate of functional decline across three dementia types
   Journal Article  Alzheimers Dement,9:S63-71,2013,PMC3766452

   PUBLISHED



3  Gill DP, Koepsell TD, Hubbard RA, Kukull WA
   Risk of decline in functional activities in dementia with lewy bodies and Alzheimer disease
   Journal Article  Alzheimer Dis Assoc Disord,25:17-23,2011,PMC3053143

   PUBLISHED



4  Gill DP, Koepsell TD, Kukull WA
   Risk of Decline in Functional Activities in Dementia with Lewy Bodies and Alzheimer's Disease
   Abstract  Neuroepidemiology,33:71,2009,

   PUBLISHED





   Proposal Description:
   The specific aims are:     1) Determine the extent to which the rate of functional decline differs among persons with AD, VaD, and DLB    2) Evaluate whether the relationship of dementia type and functional decline varies by age or sex and     3) Determine the extent to which certain dementia types are at increased risk for decline in specific activities.    The analytic sample will be drawn from all UDS enrollees who: 1) had a clinical diagnosis of dementia and a primary clinical diagnosis of probable AD, probable VaD or DLB, on any visit 2) were 60+ years of age (at baseline) and 3) had a Global Clinical Dementia Rating (CDR) score between 0.5 and 2.0 (at baseline). For aim 1, two continuous outcomes, measured at each visit, will be examined: a total score from the Functional Activities Questionnaire (FAQ) and the CDR Sum of Boxes (SOB) score from the CDR scale. Linear mixed effects models or generalized estimating equations will be used to examine the effect of dementia type on rate of functional decline while accounting for within-subject and within-center correlations in outcomes and potential confounding variables. To evaluate the degree to which age and sex alter the effect of dementia type on functional decline (aim 2), interaction terms will be tested for inclusion in models. In aim 3, we will examine four specific activities from the FAQ (and two corresponding items from the CDR). For each activity, binary outcomes of decline/no decline (over the past year) will be derived and generalized linear mixed models will be used to examine the association between odds of decline and dementia type.